Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution.
上皮与间充质相互作用的异位转移与脊椎动物颌的演化

Authors / 作者: Shigetani Y, Sugahara F, Kawakami Y, Murakami Y, Hirano S, Kuratani S.
Journal / 期刊: Science (New York, N.Y.)
Year / 年份: 2002
DOI: 10.1126/science.1068310
Publisher / 出版社: https://www.science.org/doi/10.1126/science.1068310
Abstract source / 摘要来源: https://europepmc.org/article/MED/12016315

Author abstract / 作者原文摘要
Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw, are expressed with similar patterns in the oral regions of chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were expressed in different subdivisions of the ectomesenchyme in the two species. Therefore, the homology and gene expression of the oral region are uncoupled during the transition from agnathan to gnathostome; we conclude that a heterotopic shift of tissue interaction was involved in the evolution of the jaw.

Summary basis / 解读依据
摘要解读依据已查看的索引作者摘要；如已保存全文，可用于进一步阅读。
Summary based on the inspected indexed author abstract; archived full text, when available, is provided for further reading.

Key findings / 主要发现
鸡与七鳃鳗口部区域中，参与下颌弓晚期特化的基因表达模式相似，但表观直系同源的同源盒基因分布于不同的外胚间充质分区，因此基因表达对应关系并不等同于组织的解剖对应关系。
Chick and lamprey oral regions show similar expression patterns for late mandibular-arch specification genes, but apparently orthologous homeobox genes occur in different ectomesenchymal subdivisions. Molecular expression correspondence therefore differs from the anatomical correspondence of these tissues.

Conclusions / 结论
作者推断，上皮与间充质相互作用的空间转移参与了颌的演化，体现保守发育基因可在不同解剖背景下重新部署。
The authors infer that a spatial shift in epithelial–mesenchymal interactions contributed to jaw evolution, illustrating how conserved developmental genes can be redeployed in different anatomical contexts.

Relevance / 关联说明
直接研究清单物种，或研究广义类群中的代表物种。
Direct research on the listed species or a representative of the broadly named group.